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1. In Silico Screening Studies on Methanesulfonamide Derivatives as Dual Hsp27 and Tubulin Inhibitors Using QSAR and Molecular Docking

A. Mostoufi; H. Eucefifar; F. Beygi; M. Fereidoonnezhad

Volume 29, Issue 3 , Summer 2018, , Pages 221-240

http://dx.doi.org/10.22059/jsciences.2018.67437

Abstract
  The expression of heat shock protein 27 (Hsp27) as a chaperone protein, is increased in response to various stress stimuli such as anticancer chemotherapy. This phenomenon can lead to survive of the cells and causes drug resistance. In this study, a series of methanesulfonamide derivatives as dual Hsp27 ...  Read More