2006
17
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Molecular Identification of the Most Prevalent Mutations of Glucose6Posphate Dehydrogenase (G6PD) Gene in Deficient Patients in Khorasan Province of Iran

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Glucose6phosphate dehydrogenase (G6PD) enzyme catalyses the first step in pentose phosphate pathway (conversion of glucose6phosphat to 6phospho gluconat) which provides cells with pentoses and reduction power in the form of NADPH. In the present study we have analyzed the G6PD gene mutations in 76 patients with a history of favism in Khorasan province in Iran. DNA samples were analyzed for the presence of certain known G6PD mutations by the appropriate (PCR/RFLP analysis). The results showed that similar to Gilan, Golestan and Mazandaran provinces, Mediterranean mutation is the most common G6PD variant in this area (66%). 12% of samples had Chatham mutation and none of the samples had Cosenza mutation. In comparison with the three provinces of Caspian sea shore, more samples did not have three investigated variants (22%) which required further sequencing to search for other mutations.
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Molecular Characterization of Unknown Potentially Salt Tolerant Olive Genotypes Using RAPD Markers

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Randomly amplified polymorphic DNA (RAPD) markers were used to study the genetic diversity and discriminate among 17 unknown genotypes (considered potentially salt tolerant) and 16 known olive cultivars. Fifteen decamer primers which produced 38 reproducible polymorphic bands in the genotypes were selected for analysis. The RAPD markers resulted in 93 distinct banding patterns. Based on either unique or combined patterns all genotypes could be identified. Genetic similarities between genotypes were estimated using Jaccard's similarity index indicating a high degree of diversity within the known and unknown genotypes. Using the unweighted pairgroup method (UPGMA), most genotypes were clustered into two main groups according to their origin area of cultivation (native and foreign ones). The unknown genotypes mainly clustered with cv. Zard, one of the native Iranian olive cultivars. The presented results contribute to a comprehensive understanding of unknown olive genotypes, which potentially are tolerant to the high salinity of their cultivation area. These genotypes could be important for extension of cultivation purposes and breeding programs
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Genotyping of Five Polymorphic STR Loci in Iranian Province of Isfahan

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Genotyping for five short tandem repeat (STR) loci HUMvWA, HUMFES, HUMTPO, HUMTH01 and D3S1359 was done in 220 unrelated individuals from the population of Isfahan province of IR Iran. The loci were genotyped using the polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis (PAGE) and silver staining. The data demonstrated that the STR markers were all found informative in the population examined. The markers were also found to have a relatively high degree of heterozygosity. Forensic and paternity indices including power of discrimination (PD) and exclusion (PE) as well as polymorphism information content (PIC) and typical paternity index were determined for the examined STR alleles. Together, the examined STR loci in this study could be considered for paternity testing and individual identification in Iranian population. Moreover, the data could be used in construction of the first Iranian STR genetic database.
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A Novel Method for the Synthesis of 2Ketomethylquinolines

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Several 2ketomethylquinolines were synthesized by heating, 2methyl quinoline with acyl chloride in the presence of AlCl3 Contrary to reported procedures, this method was accomplished at a short time obtaining good results.
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Silylation of Alcohols and Phenols Using HMDS Catalyzed by SiO2Cl in Solution and SolventFree Conditions

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Trimethylsilylation of a variety of alcohols and phenols, in the presence of silica chloride, using hexamethyldisilazane (HMDS) in solution and under solventfree conditions is reported. Trimethylsilyl ethers were formed in excellent yields both for aliphatic alcohols and phenols without having an electronwithdrawing group. In addition, SiO2Cl can be recovered and reused after drying.
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Major, Trace and REE geochemistry of PaleoTethys CollisionRelated Granitoids from Mashhad, Iran

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The Spatial Distribution of Some Chromite Deposits in Iran, Using Fry Analysis

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The spatial distribution of mineralization is the foremost concern in regional exploration and it could be considered as a very important tool in the investigation of mineral deposits. There are several data manipulation methods by which the data can be evaluated. Fry analysis is a good method to determine the direction(s) of maximum continuity of the deposits and could be used in different types of deposits. Chromite deposits in Iran are postulated to be related to Alpine orogen. They are mostly podiform types and irregular in their settings. The deposits are located in the ophiolite complexes of Iran. The spatial distribution of five chromite deposits using Fry analysis has been recorded and it appears that the preferred orientation of each deposit coincides with the general trend of faults in each region.
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On the Minimax Optimality of Block Thresholded Wavelets Estimators for ?Mixing Process

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We propose a wavelet based regression function estimator for the estimation of the regression function for a sequence of ?missing random variables with a common onedimensional probability density function. Some asymptotic properties of the proposed estimator based on block thresholding are investigated. It is found that the estimators achieve optimal minimax convergence rates over large classes of functions that involve many irregularities of a wide variety of types, including chirp and Doppler functions and jump discontinuities.
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Strong Convergence of Weighted Sums for Negatively Orthant Dependent Random Variables

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We discuss in this paper the strong convergence for weighted sums of negatively orthant dependent (NOD) random variables by generalized Gaussian techniques. As a corollary, a Cesaro law of large numbers of i.i.d. random variables is extended in NOD setting by generalized Gaussian techniques.
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Decomposition of H*Algebra Valued Negative Definite Functions on Topological *Semigroups

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In the present paper, among other results, a decomposition formula is given for the wbounded continuous negative definite functions of a topological *semigroup S with a weight function w into a proper H*algebra A in terms of wbounded continuous positive definite Avalued functions on S. A generalization of a wellknown result of K. Harzallah is obtained. An earlier conjecture of the author is also established.
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The Minimum Universal Cost Flow in an Infeasible Flow Network

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In this paper the concept of the Minimum Universal Cost Flow (MUCF) for an infeasible flow network is introduced. A new mathematical model in which the objective function includes the total costs of changing arc capacities and sending flow is built and analyzed. A polynomial time algorithm is presented to find the MUCF.
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