TY - JOUR ID - 31591 TI - Synthesis of Some New 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino)-2-pyridyl] piperazines as Anti-HIV JO - Journal of Sciences, Islamic Republic of Iran JA - JSCIENCES LA - en SN - 1016-1104 Y1 - 2004 PY - 2004 VL - 15 IS - 2 SP - EP - DO - N2 - A few analogues of atevirdine or 1-[(5-methoxyindol-2-yl) carbonyl]-4-[3- (ethylamino)-2-pyridyl] piperazine – an anti-HIV belonging to non-nucleoside reverse transcriptase inhibitors were synthesized and evaluated for anti-HIV activity. Replacement of indolyl moiety with 2-alkylthio-1-benzyl-5-imidazolyl substituent afforded 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino)-2-pydridyl] piperazines. The title compounds were tested for anti-HIV activity and had maximum percent of protection 14.6% at concentration of 2×10?5 M. UR - https://jsciences.ut.ac.ir/article_31591.html L1 - https://jsciences.ut.ac.ir/article_31591_53daa9ae79edf1e5d6aed39f14be0052.pdf ER -