TY - JOUR ID - 31750 TI - SYNTHESIS OF 4-(1-BENZYL-5-IMIDAZOLYL)-1,4-DIHYDROPYRIDINES JO - Journal of Sciences, Islamic Republic of Iran JA - JSCIENCES LA - en SN - 1016-1104 Y1 - 2002 PY - 2002 VL - 13 IS - 1 SP - EP - DO - N2 - The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. Primarily pharmacological studies of the title compounds have shown they have good calcium channel antagonist activities. UR - https://jsciences.ut.ac.ir/article_31750.html L1 - https://jsciences.ut.ac.ir/article_31750_1c91d92190a2ff81978d204c94b09b29.pdf ER -