TY - JOUR ID - 60749 TI - Novel Levofloxacin Derivatives as Potent Antibacterial Agents JO - Journal of Sciences, Islamic Republic of Iran JA - JSCIENCES LA - en SN - 1016-1104 AU - M. H., Moshafi AU - Bahador, N. AU - Moghimi, S. AU - Ejtemaei, R. AU - Foroumadi, A. AU - A., Asadipour AD - 1Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran AD - 2Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran AD - 2Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran+/3Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran AD - 3Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran Y1 - 2017 PY - 2017 VL - 28 IS - 2 SP - 127 EP - 131 KW - Antibacterial evaluation KW - Fluoroquinolone KW - Levofloxacin DO - N2 - In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synthesized compounds are strong antibacterial agents. All the synthesized compounds showed remarkable activities against Staphylococcus epidermidis and Staphylococcus aureus (MIC = 0.03-1 µg/mL and 0.06-1 µg/mL respectively). UR - https://jsciences.ut.ac.ir/article_60749.html L1 - https://jsciences.ut.ac.ir/article_60749_a4ba007540cb5b5bd275b37d44e58269.pdf ER -