University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 30 2 2019 04 01 The Chemoselective Fischer’s Synthesis of Indolenine Derivatives By iso-Butyric Acid As A Weak Organic Acid Catalyst 129 134 71753 10.22059/jsciences.2019.284702.1007424 EN Sami Sajjadifar Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran Issa Amini Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran Z. Navabi Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran Hadi Jabbari Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran Omidali Pouralimardan Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran Journal Article 2017 10 18 Iso-butyric acid as a new, simple, and expensive solvent/catalyst was successfully used for the chemoselective Fischer’s synthesis of indolenines derivatives 3a-r by one-pot condensation reaction of various phenylhydrazines 1a-e with the substituted acetophenones 2a-c at reflux conditions. In this protocol, all products 3a-r were obtained in high yields and short reaction time. The structures of the product were established with spectroscopic data of 1H NMR, 13C-NMR, and FT-IR. https://jsciences.ut.ac.ir/article_71753_233ba95fbf5aa623057667d1a8f91d2d.pdf