University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 33 3 2022 09 01 Balangu/Fe3O4/Ag2S/Polyurethane as an Innovative Bio-Nanocomposite Hydrogel: Synthesis, Characterization, Swelling and Drug Delivery Capacity 233 243 89700 10.22059/jsciences.2022.347040.1007746 EN Farzaneh Sheikhshoaii 1 Department of Chemistry, Payame Noor University (PNU),19395-4697, Tehran, Islamic Republic of Iran Samieh Fozooni 2 Department of Chemistry, Faculty of science, Shahid Bahonar University of Kerman, 7616913439, Kerman, Islamic Republic of Iran Hooshang Hamidian 1 Department of Chemistry, Payame Noor University (PNU),19395-4697, Tehran, Islamic Republic of Iran Journal Article 2022 08 13 The primary interest of researchers from biology, physics, medicine, chemistry, industry, and material science towards nanotechnology is the most upgrading of production methods, especially those that are cleaner and simpler. This work investigates a new Balangu-based nanocomposite made from Balangu, polyurethane, iron oxide (Fe<sub>3</sub>O<sub>4</sub>) and silver sulfide (Ag<sub>2</sub>S) nanoparticles. The bio-nanocomposite was prepared by the synthesis of Fe<sub>3</sub>O<sub>4</sub> and Ag<sub>2</sub>S nanoparticles on the Balangu matrix. Balangu is a natural and abundant, renewable polysaccharide, safe to use, non-toxic, hydrophilic, and biodegradable polymer. A mixture of Balangu/Fe<sub>3</sub>O<sub>4</sub>/Ag<sub>2</sub>S nanocomposite hydrogel and ethylene glycol was stirred at ambient temperature. After 2h, diphenyl methane diisocyanate was added and refluxed. The resulted product was filtered and washed thrice with deionized water. Subsequently, Balangu/Fe<sub>3</sub>O<sub>4</sub>/Ag<sub>2</sub>S/polyurethane nanocomposite was obtained by drying in the oven. This research was aimed at investigating the potential of this nanocomposite in drug delivery systems. Balangu/Fe<sub>3</sub>O<sub>4</sub>/Ag<sub>2</sub>S/polyurethane nanocomposite was synthesized using various Ag<sub>2</sub>S nanoparticle contents. The resulted bio-nanocomposite was evaluated by FT-IR, XRD, SEM, and TGA techniques. In vitro drug release experiments were performed to assess the efficacy of the developed nanocomposite in the controlled drug delivery systems. The Balangu/Fe<sub>3</sub>O<sub>4</sub>/Ag<sub>2</sub>S/polyurethane nanocomposite containing 0.01 M AgNO<sub>3</sub> exhibited longer and better controlled drug release. Balangu Magnetic nanocomposite drug delivery Swelling Ag2S https://jsciences.ut.ac.ir/article_89700_02e59f87ea06de35b86b9f651e35c084.pdf