University of TehranJournal of Sciences, Islamic Republic of Iran1016-110434420231201The Combined Effect of D-peptide B and Bifidobacterium bifidum Lysate on the Expression of MAP1LC3A and CASP3 Genes in Human Colorectal Adenocarcinoma Cells3053169695510.22059/jsciences.2024.363599.1007822ENNegarYavari Tehrani Fard1 Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Azad University of Medical Sciences, Tehran, Islamic Republic of IranZeynab ZeenaAmini2 College of Sport, Health and Engineering, Victoria University, Melbourne, AustraliaNahidAboutaleb3 Physiology Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of IranMaryamNaseroleslami1 Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Azad University of Medical Sciences, Tehran, Islamic Republic of IranJournal Article20230809In the realm of cancer research, novel approaches complementing conventional treatments are gaining prominence to improve patient outcomes. Antimicrobial peptides (AMPs), and bacteria, as emerging strategies, hold promise for cancer therapy. Recent studies suggested that the administration of peptides and bacteria may eliminate colorectal cancer (CRC) cells by triggering apoptosis, and autophagy processes, underscoring the potential of these compounds in CRC treatment. Using the human CRC cell line HT-29, we evaluated the combined effects of D-peptide B and <em>Bifidobacterium bifidum</em> lysate on the expression of the microtubule associated protein 1 light chain 3 alpha (<em>MAP1LC3A</em>), referred to as <em>LC3A</em> hereafter, and caspase 3 (<em>CASP3</em>) genes. D-peptide B and <em>B. bifidum</em> lysate were applied to control human embryonic kidney epithelial cell line HEK293 and HT-29 at their respective half-maximal inhibitory concentration (IC50) values. We performed total RNA extraction, complementary DNA (cDNA) synthesis, and reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) with gel electrophoresis to examine changes in the gene expression. Tukey's test and GraphPad Prism One-Way ANOVA were used for the statistical study. The combined treatment of D-peptide B and <em>B. bifidum</em> lysate with HT-29 cells resulted in a considerable decrease in the vitality of cancer cells. Furthermore, when HT-29 cells were compared to control cells, the expression of <em>LC3A</em> and <em>CASP3</em> genes increased. The results point to the possibility of combining D-peptide B with <em>B. bifidum</em> lysate as a supplementary therapy for CRC. Furthermore, these findings may help improve our knowledge of the molecular processes driving apoptosis and autophagy, as well as their potential therapeutic implications in CRC.https://jsciences.ut.ac.ir/article_96955_5e840e9a4ffbd8eabe103e987c94e8d6.pdfUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-110434420231201Petrogenesis and Sr-Nd isotope Geochemistry of Neogene Igneous Rocks in the Goloumak Area, South of Kerman, Iran3173329621810.22059/jsciences.2023.361095.1007806ENFarzanehArzhangnegad1 Department of Geology, University of Hormozgan, Bandar Abbas, Hormozgan, Islamic Republic of IranGholamrezaGhadami2 Department of Geology, University of Hormozgan, Bandar Abbas, Hormozgan, Islamic Republic of IranMohammadPoosti3 Department of Geology, University of Hormozgan, Bandar Abbas, Hormozgan, Islamic Republic of IranMohammadFadaeian4 Department of Geology, Payame Noor University, Tehran, Islamic Republic of IranJournal Article20230620The study area is near Goloumak village, 30 km south of Kerman. These rock units consist of acidic rhyolite and dacite, as well as intermediate andesite, basalt, and trachy-andesite. Mafic igneous rocks are alkaline, and intermediate rocks are calc-alkaline to transition range. Volcanic rocks exhibit depletion in Ba, Ti, Nb, and Ta, as well as enrichment in K, Rb, and Th. Basaltic rocks were formed by partial melting of the mantle, based on 87Sr/86Sr and 144Nd/143Nd isotopic ratios. Samples show relative enrichment of 87Sr/86Sr in the mantle array on the Sr-Nd isotope correlation diagram. Mafic rocks are affected by subduction of lithospheric slab or mantle crust metasomatism, as per the comparison of studied samples in the 143Nd/144Nd isotope correlation diagram versus 87Sr/86Sr. Based on Sr-Nd geochronological data, the rocks were formed at 12.5 ±2.0 Ma, corresponding to the Miocene for the basaltic rocks. All samples are in a continental arc margin and post-collision volcanic arc. The magma source is from low to intermediate partial melting of the mantle, as indicated by the LREE/HREE ratio of the mafic and intermediate rocks. LREE enrichment is due to low partial melting of mantle source and magma contamination by crust materials. Basalts show a low melting degree of the mantle for magma formation. Depletion of these rocks of HREE in the source shows garnet in genesis. La and Sm abundance in the studied composition is similar to magma derived from the enriched mantle, comprising about 1-5% of lherzolitic garnet.https://jsciences.ut.ac.ir/article_96218_538021d3425e9a8aebbb26dbe10ae2b9.pdfUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-110434420231201Maximum Approximated Likelihood Estimation in Generalized Linear Multilevel Model for Nominal Response with Covariates Subject to Measurement Error3333489695810.22059/jsciences.2024.361467.1007811ENMaryamAhangari1 Department of Statistics, Tarbiat Modares University, Tehran, Islamic Republic of IranMousaGolalizadeh1 Department of Statistics, Tarbiat Modares University, Tehran, Islamic Republic of IranZahraRezaei Ghahroodi2 School of Mathematics, Statistics and Computer Science, University of Tehran, Tehran, Islamic Republic of IranJournal Article20230628Ignoring measurement errors in generalized linear mixed models (GLMMs) as well as other regression models will inevitably lead to significant biases, deviations, and incorrect inferences in the estimation of the parameters. In the presence of measurement error, numerous approaches have been proposed to rectify this issue. Furthermore, the application of the frequentist approach of GLMMs is intricate due to the emergence of an intractable numerical integration process. In this study, the complete likelihood inference of a multinomial logit random effects model with covariate measurement error in conjunction with replicate measures is suggested via the multivariate Gauss-Hermite quadrature approximation. To achieve this objective, the likelihood function will be evaluated and approximated for two distinct scenarios; the proposed method which incorporates the classical additive structural measurement error model for the error-prone covariate and the naive method. We will describe and compare different upshots of parameter estimation in these two different situations. The results of performing the proposed method, assessed through simulation, show that the proposed method performs well when correcting for measurement error in terms of bias, empirical standard error, root of mean squared error and coverage ratio. The application of the proposed method is further highlighted with real-world data based on a multilevel study concerning the prevalence of contraceptive methods used by women in Bangladesh.https://jsciences.ut.ac.ir/article_96958_86ec1bfb020b5c9d3381d01352610ee8.pdfUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-110434420231201Beta Kernel Estimator for a Cumulative Distribution Function with Bounded Support3493619621910.22059/jsciences.2024.367933.1007836ENBehzadMansouriDepartment of Statistics, Shahid Chamran University of Ahvaz, Ahvaz,Islamic Republic of IranAzamRastinDepartment of Statistics, Shahid Chamran University of Ahvaz, Ahvaz,Islamic Republic of IranHabib AllahMombeniDepartment of Statistics, Shahid Chamran University of Ahvaz, Ahvaz,Islamic Republic of IranJournal Article20231120Kernel estimation of the cumulative distribution function (CDF), when the support of the data is bounded, suffers from bias at the boundaries. To solve this problem, we introduce a new estimator for the CDF with support (0,1) based on the beta kernel function. By studying the asymptotic properties of the proposed estimator, we show that it is consistent and free from boundary bias. We conducted an extensive simulation to illustrate the performance of the proposed estimator. The results demonstrate the superiority of the proposed estimator over other commonly used estimators. As an application, we use the estimated CDF for nonparametric simulation. Using a numerical study, we show that the performance of the kernel probability density function (PDF) estimation in which a large sample simulated from the estimated CDF is employed can be noticeably improved. We also use the proposed estimator to estimate the CDF of the household health cost in Iran in 2019.https://jsciences.ut.ac.ir/article_96219_3b53bf4d214c48a830522a813de61c0c.pdfUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-110434420231201GeV-Scale Electron Acceleration in a Magnetized Plasma-Filled Waveguide by Twisted Electromagnetic Waves3633699377810.22059/jsciences.2023.361092.1007805ENBahramBarzegarDepartment of Physics and Institute for Plasma Research, Kharazmi University, Tehran, Islamic Republic of IranAliHasanbeigiDepartment of Physics and Institute for Plasma Research, Kharazmi University, Tehran, Islamic Republic of IranHassanMehdianDepartment of Physics and Institute for Plasma Research, Kharazmi University, Tehran, Islamic Republic of IranKamalHajisharifiDepartment of Physics and Institute for Plasma Research, Kharazmi University, Tehran, Islamic Republic of IranJournal Article20230620In this paper, a test particle model is developed to study the electron acceleration in a magnetized plasma-filled waveguide by a twisted electromagnetic wave with variable amplitude and phase along the longitudinal position. With appropriately assigned initial values, the electron total energy gain is obtained using numerical analysis without calculating the dispersion relation. Numerical results show that as long as the twisted electromagnetic waves significantly affect the electron acceleration, during the passage of an electron through the waveguide, one may employ an optimum value of the external magnetic field to obtain the maximum energy gain.https://jsciences.ut.ac.ir/article_93778_85671922b133c6f04f1370fa3703895c.pdfUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-110434420231201Adomian Decomposition Approach to Solve the Quantum Mesoscopic Nonlinear LC-circuits with Charge Discreetness3713779695710.22059/jsciences.2024.358905.1007800ENHasanPahlavaniDepartment of Physics, University of Qom, Qom, Islamic Republic of IranAmenhZamaniDepartment of Physics, University of Qom, Qom, Islamic Republic of IranJournal Article20230514The quantum Hamitonian of a nonlinear mesoscopic LC-circuit include a nonlinear inductor and a linear capacitor with charge discreetness is introduced. An analytical function for quantum persistent current due to the magnetic flux of such nonlinear electrical circuit is obtained by Adomian Decomposition Method (ADM). The nonlinear quantum ring is introduced and the quantum persistent current and the eigenvalues energy are found analytically. It is shown by numerical solution that the persistent current and eigenvalues energy are periodic functions of the magnetic flux with the fundamental parameter ( ), which is a pure quantum characteristic. In this paper, we proved for the first time that in a mesoscopic nonlinear quantum ring, similar a linear quantum ring, there is a quantized and periodic persistent current in terms of magnetic flux, which will attract attention in experience and technology.https://jsciences.ut.ac.ir/article_96957_168b2badd9f66af215f7e1cd9c20b707.pdf