University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 STUDIES ON THE TISSUE SPECIFICITY OF COLONY STIMULATING FACTOR - 31438 EN Journal Article In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both rabbit and guinea pig lung tissues produced and released CSF in the conditioned medium. The CSFs were active on ammonium chloride treated bone marrow cells from balblc mouse and on their own ammonium chloride treated bone marrow cells but could not stimulate the progenitor cells from other sources https://jsciences.ut.ac.ir/article_31438_b0784fd78e6211f2c634896ef544cfe0.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 A MATHEMATICAL MODEL TO DESCRIBE THE SYNERGISTIC EFFECT BETWEEN SULFAMETHOXAZOLE AND TRIMETHOPRIM - 31439 EN Journal Article b a s e don folic acid biosynthetic pathway a mathematical model was made for bacterial growth to describe the synergistic effect between sulfamethoxazole and trimethoprim. The results obtained show a strong synergism at growth inhibiting concentrations of these two drugs. Two cyclic pathways included in the model are responsible for this synergism. The roles of these pathways in producing synergism are discussed. https://jsciences.ut.ac.ir/article_31439_a91a50a0d0efd57e5e844a749fee53fb.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 A QUANTUM CHEMICAL STUDY OF THE CONFORMATION OF ALINIDINE A NEW ANTIARRHYTHMIC AGENT - 31440 EN Journal Article The conformation of alinidine a new and specific bradycardic agent was studied using MNDO method. It has been found that the rotation of both phenyl and imidazoline ring of this compound is restricted. Of two possible isomers of irnidazoline ring, the one with NH in the cis position to allyl side chain is slightly more stable. On the other hand, the allyl group can rotate freely and at least six more conformers besides that of global minima has been identified. These calculations show that alinidine has a rather flexible structure and suggest that synthesis of more rigid analogs of this compound may be interesting from the structure-activity point of view https://jsciences.ut.ac.ir/article_31440_31429ccef08e1dfc4839ba23a3d2443a.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 DETECTION OF CROSS-LINmD PERIDES BY FAST ATOM B01WBARDMENT MASS SPECTROMETRY - 31441 EN Journal Article The possibility of chemical modification of peptides and proteins under the condition of proteolytic digestions and FABMS analysis was investigated. The results ;indicate that among the amino acid constituents of peptides and proteins: serinefcysteine, and cystine are the most sensitive residues which undergo chemical modificadons under the exprimenta1 conditions. The chemical modification of these amino acids which is governed by the intrinsic properties of the peptides will result in the formation of a molecular ion mass which is 16 mu lower than the molecufitir ion of the parent peptide, MHf. Exact mass measurements of (MH-16) molecular ions indicate that these ions may cornspond to(MH-H O +H ) but not(MH-CH ) molecules. In addition, the results indicate the presence of no inter-and /or intrachain disulfide bond rearrangements uhder the experimental conditions of degradations and FABMS analyses of Lysozyme and Rihonuclease A. https://jsciences.ut.ac.ir/article_31441_6bf3f9188c022dc72696c329a4d47b8f.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 ON THE COMPLEXING ABILITY OF ERIOCHROME BLACK T AS A METALLOCHROMIC INDICATOR FOR SOME ALKALI AND ALKALINE EARTH CATIONS IN ACETONE AND DIMETHYLSULPHOXIDE SOLUTIONS - 31442 EN Journal Article The interaction between eriochrome black T and Li , Na , K ,Mg and Ca ions in acetone and dimethylsulphoxide solutions has been investigated spectrophotometrically. The formation constants of the resulting 1 : 1 complexes were determined and found to decrease in the order Mg >Ca >Li >K >Na in both solvents used. There is an inverse relationship between the stabilities of the complexes and the solvating ability of the solvents https://jsciences.ut.ac.ir/article_31442_432267328656d29d7ca6f72297aebb9d.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 SYNTHESIS AND MOLECULAR STRUCTURE OF TETRAAQUA [2,9 -DIFORMYL- 1,10 PHENANTHROLINE BIS (SEMICARBAZONE)] CERIUM(III) PERCHLORATE, [Ce(PHENSC(H O) ] (CLO ) - 31443 EN Journal Article The complex of Ce(III), [ Ce (PHENSC) (H 0) ] (C10 ) , was synthesized using the PHENSC, a hexadentate ligand,2,9-diformyl-1,lO- Phenanthroline bis (semicarbazone), and characterized by X-ray diffraction. The cerium atom has an unusual coordination number of ten involving six donor atoms of the planar ligand in the equatorial plane and four oxygen atoms from four axial water molecules. The complex crystallizes in the monoclinic space group P2,k with four molecules per unit cell. The unit cell dimensions are cz = 16.085(3), b = 12.229 (4), and c=15.436(4) ?with ?= 95.20 (2)? . The position of the cerium atom was determined by the heavy atom method and refined by least-squares techniques to a final R value (R = |?F| / ? | F | of 0.071 for the 3166 reflections used in the analysis. The coordination polyhedron is probably best described in terms of 1-6-3 polyhedron https://jsciences.ut.ac.ir/article_31443_7c10793762778883d5b39d05bd64fea2.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 STUDIES ON HYDRALAZINES - PART-1x1 PREPARATION AND ANTIMICROBIAL ACTIVITY OF 1 - (PHTHALAZIN- 1 '-YLAMINO)- 3-CHLORO-4-ARYL- 4H-(OR 4-METHYL)-2-AZETIDINONE - 31444 EN Journal Article 1- (Phthalazin-l'-yl-amino)-3-chloro-4-aryl-4H-(4o-rm ethyl)-2-azetidinones (3) were prepared by cycloaddition of-methyl substituted benzal hydrazinophthalazine (2) with chloro acetylchloride. The hydrazone (2) was synthesised by the condensation of 1- hydrazinophthalazine (1) with substituted aromatic aldehydes, ketones 7 acetophenones. 1- Hydrazinophthalazine was prepared from the phthalaldehydic acid. All the compounds thus synthesised (2 and 3) were tested against different species of bacterial and fungi. Their structures have been ktermined by NMR and Mass spectroscopy https://jsciences.ut.ac.ir/article_31444_25d55f01734adca809111ca46b5344c0.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 DERIVING THE EQUATION OF STATE FOR LIQUIDS AND EXTENSION OF THE PRINCIPLE OF CORRESPONDING STATES - 31445 EN Journal Article A new simple model is introduced for a liquid and an equation of state is derived based on this model and the statistical mechanical calculations. This equation of state works well for the non-polar and slightly polar liquids. The important conclusion that may be deduced from this equation of state is that if the reduced variables of state are chosen and defined appropriately, then, the principle of corresponding states works well for liquids, and it may even be unnecessary to use an additional parameter like the acentric factor https://jsciences.ut.ac.ir/article_31445_82d584b97651cd1b10ae553c61803c61.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 PERMIAN-TRIASSIC BOUNDARY OF INDIAN SUBCONTINENT AND ITS INTERCONTINENTAL CORRELATION - 31446 EN Journal Article The Permian-Triassic boundary in the Himalayas is reviewed and discussed in the light of palaeontologic and stratigraphic data collected during the past two and a half decades from Kashmir, Spiti and Nepal. The deposition of the Kuling Shales and their equivalents in different parts of the Himalayas was followed by shallowing and regression of the sea. Sedimentation was interrupted at the top of Kuling Shale sequence resulting in the emergence of many areas. This was followed by widespread and simultaneous marine transgression resulting in deposition of Otoceras-bearing beds. Otoceras woodwardi Zone has been assigned to the Griesbachian age. The base of Ophiceras tibeticum Zone corresponds to the base of Isarcicella isarcica conodont zone; the disappearance of Otoceras, Permian brachiopods and other holdovers. It is suggested that the base of Gyronites frequens Zone is the most befitting for demarcating and documentation of the Perrnian- Triassic boundary as this stratigraphic level corresponds to the end of the lowest faunal diversification and coincides with the Griesbachian-Dienerian boundary. This boundary is also marked by striking changes in conodont fauna from Anchignathodus and Zsarcicella to Kashmirella and Neospathodus https://jsciences.ut.ac.ir/article_31446_70fc8a17ae8984aaa705b62f3e9ef2df.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 AN ALGORITHM FOR FINDING THE STABILITY OF LINEAR TIME-INVARIANT SYSTEMS - 31447 EN Journal Article The purpose of this paper is to show that the ideas and techniques of the classical methods of finding stability, such as the criteria of Leonhard and Nyquist, can be used to derive simple algorithm to verify stability. This is enhanced by evaluating the argument of the characteristic equation of a linear system in the neighbourhood of the origin of the complex plane along the imaginary axis https://jsciences.ut.ac.ir/article_31447_be1fe5a4cbad9fd763db5aaedf0ec611.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 COMPUTATIONAL ENUMERATION OF POINT DEFECT CLUSTERS IN DOUBLE- LATTICE CRYSTALS - 31448 EN Journal Article The cluster representation matrices have already been successfully used to enumerate close-packed vacancy clusters in all single-lattice crystals [I, 2]. Point defect clusters in double-lattice crystals may have identical geometry but are distinct due to unique atomic postions enclosing them. The method of representation matrices is extended to make it applicable to represent and enumerate the point defect clusters in multi-lattice crystals as well. A computational procedure based on family representation matrices is developed and applied to the hexagonal close-packed structure. https://jsciences.ut.ac.ir/article_31448_4a85893ded100b9f592f36a9e9473a7c.pdf

University of Tehran Journal of Sciences, Islamic Republic of Iran 1016-1104 2 2 1991 12 01 AXIAL FLOW IN A ROTATIONAL COAXIAL RHEOMETER SYSTEM 1. BINGHAM PLASTIC - 31449 EN Journal Article A mathematical analysis has been carried out for the axial flow of a Bingham plastic fluid, in the Concentric Cylinder Viscometer which consists of a cylindrical sample holder (the cup) and a cylindrical spindle (the bob) coaxial with the cup. The fluid to be tested flows through the annular gap of the cup and the bob system, sheared by the rotation of the inner cylinder, while the outer cylinder is held stationary. This is a case of helical flow in an annular region. An attempt has been made to direct the analysis toward an examination of the relationship between moment (M) and angular velocity (?) at the inner cylinder. Since M and ? are proportional to the shear stress and shear rate respectively, we may thus investigate the relationship between shear stress and shear rate and the dependence of this on axial flow rate. We have shown using numerical solutions that axial flow has no effect on shear rate. A definition for an approximate viscosity has been presented and a comparison has been made between predicted approximate and true viscosity https://jsciences.ut.ac.ir/article_31449_f36c95070399e5d69f5ae982b8b664f6.pdf