University of TehranJournal of Sciences, Islamic Republic of Iran1016-110427120160101Phylogeography of Calomyscus elburzensis (Calomyscidae, Rodentia) around the Central Iranian Desert with Description of a New Subspecies in Center of Iranian Plateau52156004ENS.Akbarirad1 Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Islamic Republic of IranJ.Darvish1 Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Islamic Republic of IranM.Aliabadian1 Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Islamic Republic of IranJournal Article20150124<em>Calomyscus elburzensis</em> Goodwin, 1938, was previously known from central and northern Iran to southern and southwestern Turkmenistan and northwestern Afghanistan. Its type locality is at altitude of 1200m elevation in the Kurkhud Mts., North Khorasan province in northeastern Iran. This study <span>provides new evidence that its range is more extensive than thought previously </span>and central Iranian Mountains, Shirkuh (Yazd province)and Karkas Mts. in Isfahan and Zanjan provinces in the northwest were recognized as its distribution areas. Two major clades were detected within <em>C. elburzensis</em> from the analysis of two mitochondrial genes <em>Cytb</em> and <em>CoI</em>. The outline on m2 and karyotypes analyses also supported these two molecular clades; one northeast with 2n=44 and FN<sub>a</sub>=58, 60 and 62 and the other west and northwest of central Iranian desert with 2n=44 and Fn<sub>a</sub>=70.The Statistical Dispersal-Vicariance Analysis (S-DIVA) suggested dispersal events from north east to the center of Iran occurred in two separate occasions. As 2.5% was the rather low level of sequence divergence between these two major clades, we assigned the central-northwestern brush-tailed mice as a subspecies of <em>C. elburzensis </em>and therefore we named as <em>C. e. isatissus </em>ssp. novo.University of TehranJournal of Sciences, Islamic Republic of Iran1016-110427120160101Direct Bisulfite Sequencing and Methylation Specific PCR to Detect Methylation of p15INK4b and F7 genes in Coronary Artery Disease Patients232956005ENM.Yari1 Department of Medical Genetics, Faculty of Medicine, University of Shahid Beheshti Medical Sciences, Tehran, Islamic Republic of Iran.A.Movafagh1 Department of Medical Genetics, Faculty of Medicine, University of Shahid Beheshti Medical Sciences, Tehran, Islamic Republic of Iran.A.Sayad1 Department of Medical Genetics, Faculty of Medicine, University of Shahid Beheshti Medical Sciences, Tehran, Islamic Republic of Iran.M. D.Omrani1 Department of Medical Genetics, Faculty of Medicine, University of Shahid Beheshti Medical Sciences, Tehran, Islamic Republic of Iran.M. A.Broumand2 Department of Molecular Pathology, Tehran Heart Center, University of Tehran Medical Sciences, Tehran, Islamic Republic of Iran.K.Majidzadeh-A3 Department of Breast Cancer Genetics, Breast Cancer Research Center (BCRC), University of Tehran, Tehran, Islamic Republic of Iran.R.Mirfakhraie1 Department of Medical Genetics, Faculty of Medicine, University of Shahid Beheshti Medical Sciences, Tehran, Islamic Republic of Iran.A.Khoshdel4 Department of Medical Sciences, Faculty of Medicine, University of AJA, Tehran, Islamic Republic of Iran.K.Amini4 Department of Medical Sciences, Faculty of Medicine, University of AJA, Tehran, Islamic Republic of Iran.Journal Article20151017<span>Genome-Wide Association Studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (CAD). F7 gene because of its role in activating the extrinsic pathway by the exposure of tissue factor after plaque disruption is related to atherothrombosis. The aim of the present study was to evaluate methylation status of two CAD related genes, p15INK4b and F7, in Iranian patients with coronary artery disease (CAD). Thirty samples from 15 male and 15 female with diagnosed 3 vessels disease CAD and 60 Samples from 60 non-CAD controls who underwent coronary angiography was analyzed by MSP and direct sequencing. DNA methylation levels at p15INK4b gene increased significantly in CAD patients in comparison with control group (p-value<0.001). To quantitative analysis of methylation, direct bisulfite sequencing method revealed 6 methylated CpGs islands. No significant difference in F7 promoter methylation was observed between CAD patients and control group. Based on the findings of this study it is possible to assume, p15INK4b methylation is associated with pathophysiology of CAD.</span>University of TehranJournal of Sciences, Islamic Republic of Iran1016-110427120160101Mn-Metal Organic Framework as Heterogenous Catalyst for Oxidation of Alkanes and Alkenes313756006ENF.FarzanehDepartment of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P.O.Box 1993891176, Vanak,Tehran, Islamic Republic of IranL.HamidipourDepartment of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P.O.Box 1993891176, Vanak,Tehran, Islamic Republic of IranJournal Article20150829<span>Manganese metal-organic framework (Mn-MOF) containing Mn<sup>2+</sup> ions, benzenetricarboxylic acid (BTC) and <em>N</em>,<em>N</em>-dimethylformamid (DMF) was prepared and used as catalyst for oxidation of alkenes such as 1,1-diphenylethylene, <em>trans</em>-stilbene, cyclohexene, norbornene, styrene and cyclooctene to epoxides with 33-92% conversion and 75-100% selectivity and oxidation of alkanes such as fluorene, adamantane, ethylbenzene and diphenylmethane to alcohols or ketones with <em>tert-</em>butylhydroperoxide (TBHP) with 19-64% conversion and 80-100% selectivity. Study of the catalyst stability and reusability revealed that Mn-MOF behaves heterogeneously in the oxidation reactions</span><span>. </span>University of TehranJournal of Sciences, Islamic Republic of Iran1016-110427120160101Novel Approach Synthesis, Molecular Docking and Cytotoxic Activity Evaluation of N-phenyl-2,2-dichloroacetamide Derivatives as Anticancer Agents394956007ENM.Fereidoonnezhad1 Department of Medicinal Chemistry and Pharmaceutical Sciences Research Centre, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.Z.Faghih1 Department of Medicinal Chemistry and Pharmaceutical Sciences Research Centre, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.A.Mojaddami1 Department of Medicinal Chemistry and Pharmaceutical Sciences Research Centre, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.S. M. H.Tabaei1 Department of Medicinal Chemistry and Pharmaceutical Sciences Research Centre, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.Z.Rezaei1 Department of Medicinal Chemistry and Pharmaceutical Sciences Research Centre, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.Journal Article20150721<span>Dichloroacetate (DCA) as a small, cheap and available anticancer agent, is a pyruvate mimetic compound that stimulates the activity of pyruvate dehydrogenase (PDH) enzyme through inhibition of pyruvate dehydrogenase kinases (PDHK1-4). DCA turns on programed cell death (apoptosis) which suppressed in tumor cells and therefore inhibits tumor growth. DCA also interferes with the glucose uses of cancer cell, ravenous the cell of energy, but it does not starve normal cells of glucose. In the present study, using a novel synthetic method, we synthesized a series of N-phenyl-2,2-dichloroacetamide derivatives and evaluated their cytotoxic activities against various human cancer cell lines including NCI-H460 (lung cancer), HCA-7 (colon cancer) and MCF-7 (breast cancer). Toxicity risk factors of each compound were calculated. Docking studies were also done to find their binding site to PDHK receptor. The result showed that all synthesized compounds had an acceptable anti-cancer activity. Among them, the best compound was 2,2-dichloro-N-(3-((trifluoromethyl)sulfonyl) phenyl) acetamide (25) which had an IC50 of 6.5 μM against NCI-H460 cells, 10.5 μM against HCA-7 cells and 9.4 μM against MCF-7 cells. Toxicity risk factors studies have also implied that this compound is the best one in this series. Therefore, compound 25 might have a potential value for further study in drug development.</span>University of TehranJournal of Sciences, Islamic Republic of Iran1016-110427120160101Phospho Sulfonic Acid Catalyzed Synthesis of Benzimidazole, Benzoxazole and Quinoxaline Derivatives under Green Solvent at Ambient Temperature516356008ENS.Rezayati1 Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of IranM.Mehmannavaz1 Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of IranE.Salehi2 Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Islamic Republic of IranSh.Haghi1 Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of IranR.Hajinasiri3 Chemistry Department, Qaemshahr Branch, Islamic Azad University, POBOX 163, Qaemshahr, Islamic Rpublic of IranS.Afshari Sharif Abad3 Chemistry Department, Qaemshahr Branch, Islamic Azad University, POBOX 163, Qaemshahr, Islamic Rpublic of IranJournal Article20150520<span>Phospho sulfonic acid (PSA) synthesized as an environmentally safe and efficient solid acid catalyst, and it used for the synthesis of several 2-disubstituted benzimidazoles, 2-substituted benzoxazoles, and 2-substituted quinoxalines in ethanol as a green solvent at ambient temperature is described. (i) A very simple, green and efficient procedure for the synthesis of benzimidazole and also benzoxazole derivatives comprising the reaction of corresponding ortho-phenylenediamine or ortho-aminophenol with various aromatic aldehydes in absolute ethanol at ambient temperature is described. (ii) The direct condensation of various 1,2-diamines and carbonyl compounds in absolute ethanol at ambient temperature has been described to the synthesis of quinoxaline derivatives as biologically interesting compounds. Additionally, PSA is reused repeatedly for six reaction cycles without any evidence loss of activity. This green procedure offers significant advantages in terms of its simplicity, reusable strategy for the efficient synthesis of benzimidazole derivatives, the elimination of corrosive liquid acids, short reaction time, high product yields, and simple preparation of the catalyst.</span>University of TehranJournal of Sciences, Islamic Republic of Iran1016-110427120160101Using of ASTER, ETM+ and Gamma Spectrometry Airborne Data to Find the Relationship Between the Distribution of Alkali Metasomatism and REE Mineralization in the Bafq Area, Central Iran657756009ENK.Khoshnoodi1 Department of Geology, Faculty of Earth Science, University of Shahid Beheshti, Tehran, Islamic Republic of IranM.Yazdi1 Department of Geology, Faculty of Earth Science, University of Shahid Beheshti, Tehran, Islamic Republic of IranM.Behzadi1 Department of Geology, Faculty of Earth Science, University of Shahid Beheshti, Tehran, Islamic Republic of IranM.Gannadi-Maragheh2 Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Islamic Republic of IranJournal Article20150117<span>The study area is located in the central Iranian tectono-magmatic zone, which is known for its world-class IOA-type Iron ore deposits. The Advanced Space borne Thermal Emission and Reflection Radiometer (ASTER) and Landsat Enhanced Thematic Mapper Plus (ETM+) image-processing techniques, were used in satellite imagery through conventional and also modern processing methods including band ratios, color composite ratio images and spectral angle mapper to study the spectral discrimination of metasomatically altered rocks based on their mineral assemblages and to investigate critically the link between the distribution of Na-metasomatism and occurrence of REE mineralization through plotting the image processing results on preexisting airborne radiometric data. The achieved information points the matter that the distribution of the metasomatized rocks, in common, and Na-metasomatized rocks, in particular, are coincide with the areas with high radioactivity revealed during an airborne radiometry program. A stage of field study associated with ground spectrometry survey carried out to control some localities and showed such correlation mainly around and within some magnetite ore deposits through which two phases of albitization were revealed, namely, a widespread albitization phase within which the spectrometric survey showed normal amounts of radioactive elements and another phase that affected smaller areas and showed REE anomaly and the Na-metasomatites of which are, experimentally, more reddish in colure (meaty color in hand specimens). The Iron deposits are, chronologically, hosted in upper Proterozoic-lower Cambrian volcano-magmatic units associated with a widespread phase of Na-metasomatism, economically, resulted in enrichment of the host rocks in REE bearing mineral phases.</span>University of TehranJournal of Sciences, Islamic Republic of Iran1016-110427120160101A New Modification of the Reconstruction of Variational Iteration Method for Solving Multi-order Fractional Differential Equations798656010ENE.HesameddiniDepartment of Mathematics, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz, Islamic Republic of IranA.RahimiDepartment of Mathematics, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz, Islamic Republic of IranJournal Article20140906<span>Fractional calculus has been used to model the physical and engineering processes that have found to be best described by fractional differential equations. For that reason, we need a reliable and efficient technique for the solution of fractional differential equations. The aim of this paper is to present an analytical approximation solution for linear and nonlinear multi-order fractional differential equations (FDEs). The fractional derivatives are described in the Caputo sense. In this work, the Reconstruction of Variational Iteration Method (RVIM) technique has been successfully used to solve two types of multi-order fractional differential equations, linear and nonlinear. For this purpose, we convert FDE in to a counterpart system and then using proposed method to solve the result system. Advantage of the RVIM, is simplicity of the computations and convergent successive approximations without any restrictive assumptions. Illustrative examples are included to demonstrate the validity and applicability of the presented technique.</span>