Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2-
arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3
yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl
(or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2-
pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l-methyl-5-
nitroimidazole-2-carboxaldehyde (7) with 6 in ethanol afforded compound 8 in good
yield. The antibacterial and antifungal activities of compounds 5,6 and 8 were