Document Type: Original Paper

Authors

Department of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of Iran

Abstract

An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green chemistry catalyst system under solvent-free conditions described. Compared with the classicalBiginelli reaction conditions, this method has the advantages of good to excellent yields (80-99%) and short reaction time.

Keywords