Replacement Hydrogen with Deuterium element that a new synthesis of serial drugs

Al-kinany, Sura Q.; Sharhan, Hussain Inayah; Mohammed Al-Kazazz, Fatin Fadhel

doi:10.22059/jsciences.2026.398432.1007941

Replacement Hydrogen with Deuterium element that a new synthesis of serial drugs

Articles in Press

Document Type : Review Articles

Authors

Sura q. Al-kinany

Hussain Inayah Sharhan

Fatin Fadhel Mohammed Al-Kazazz

Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.

10.22059/jsciences.2026.398432.1007941

Abstract

The electrolysis of heavy water may produce deuterium (D), the naturally occurring isotope of hydrogen. Nature is rich in deuterium; the typical human body has more than 1 gram of this element. Human clinical trials examining pharmacokinetics and metabolism have made extensive use of deuterium, a stable and non-radioactive cousin of hydrogen. Within a pharmacological molecule, deuterium takes on the same size and shape as hydrogen, which is a crucial characteristic. Hence, chemical compounds exhibiting isotopic, structural, and kinetic consequences are the outcome of deuterium's selective replacement of hydrogen. In turn, these activities provide deuterated molecules with unique medicinal characteristics. The potential for better medication effectiveness, safety, and tolerability may be realized by the enhancement of bond strength in particular modified molecules. This, in turn, can have a favorable effect on the ADME aspects of some pharmaceuticals. From a drug-development standpoint, this is one of deuterium's most compelling properties. The structural change known as deuteration may improve the pharmacokinetic and/or toxicological properties of medications, making them more effective and safer than their non-deuterated counterparts.

Keywords

Aspirin

Deuterium

H/D exchange

Deuteration

Deuterium oxide

Subjects