Author

• A. Shafiee

Tehran University of Medical Sciences

Abstract

A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydropyrimidine derivatives were studied using 1HNMR.

Keywords

• 1
• 4-Dihydropyrimidines
• 4-Hexahydroquinoline
• Thiazoles
• 1-4-Dihydropyridine