ISOLATION AND STRUCTURAL ELUCIDATION OF THE FIRST KNOWN C-HOMOPROTOBERBERINE

Abstract

A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from
the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS,
NMR).