The relationship between aluminium toxicity and iron metabolism was studied.
Male rats were exposed to aluminium by daily intraperitoneal injection of 40pmolelkg
body weight. After 45 days, aluminium intoxified rats had a significant loweredserum
ferritin (55%), iron (42%), TIBC (25%) and hemoglobin(31%). At thesame time the
serum ceruloplasmin level was elevated by 60%. This result shows that aluminium
interferes with the iron metabolism in rats and might be considered as a possiblecause
of hypochromic microcytic anemia which is found following regular hemodialysis in
chronic renal failure patients