Techniques of immobilization of microbial- cells have been established
by multifunctional reagents such as glutaraldehyed on a solid support.
Immobilized cell reactor was designed to demonstrate stability of cross
linking of whole cells for the production of organic acids. An eighty-six
percent conversion of glucose was obtained for an eight hour retention
time. The immobilized cell reactor is about 5-8 times faster than the
continuous stirred tank reactor with free microbial cells. An appropriate
kinetic model was obtained using immobilized propionibacterium acidipropionici
on solid support