THE ROLE OF CHLOROMETHYL ETHERS IN THE FORMATION OF N(7) - AND N(9)-ALKYLATED ISOMERS OF ADENINE SYNTHESIS OF 2-[9-(ETHOXYMETHYL) ADENYL] PHOSPHONATE

Abstract

The structural features of chloromethyl ethers are shown to have a significant effect on the formation of N(7)- or N(9)- alkylated isomers of purine acyclo-nucleosides. The chemical synthesis of 2-[9-(ethoxymethyl) adenyl] phosphonate is described. This compound is active against herpesviruses.