Reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1)
with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5-
nitroimidazole 4-substituted -2- thiazolylhydrazones (3). Reaction of
thiochromitn-4-one (4) with thiosemicarbazide gave thiochroman-4- one
thiosemicarbazone (5). Reaction of compound 5 with clc- haloaldehyde or
ketones y ielded thiochroman--#-one 4-substituted-2-thiazolylhydrozones(6).
The antibacterial and antifungal activities of compounds 3 and 6 against a
number of microorganisms were determined