A MATHEMATICAL MODEL TO DESCRIBE THE SYNERGISTIC EFFECT BETWEEN SULFAMETHOXAZOLE AND TRIMETHOPRIM

Abstract
b a s e don folic acid biosynthetic pathway a mathematical model was made for
bacterial growth to describe the synergistic effect between sulfamethoxazole and
trimethoprim. The results obtained show a strong synergism at growth inhibiting
concentrations of these two drugs. Two cyclic pathways included in the model are
responsible for this synergism. The roles of these pathways in producing synergism
are discussed.