Chemoselective Synthesis of 1,1-diacetate Using Ni2+@ Hydroxyapatite-core@shell γ-Fe2O3 Nanoparticles as an Efficient and Reusable Lewis Acid Catalyst under Solvent Free Conditions

Rezaee Nezhad, E.

Chemoselective Synthesis of 1,1-diacetate Using Ni2+@ Hydroxyapatite-core@shell γ-Fe2O3 Nanoparticles as an Efficient and Reusable Lewis Acid Catalyst under Solvent Free Conditions

Document Type : Original Research Articles

Author

E. Rezaee Nezhad

1Department of Chemistry, Payame Noor University, PB BOX 19395-4697 Tehran, Islamic Republic of Iran

Abstract

A simple and efficient method for the chemoselective 1,1-diacetate protection of aromatic aldehydes with acetic anhydride by using Ni²⁺ supported on hydroxyapatite-core-shell magnetic γ-Fe₂O₃ nanoparticles (γ-Fe₂O₃@HAp-Ni²⁺) under solvent free conditions. This method has several advantages, including high yield, short reaction time, simple work-up and recyclable property of the catalyst. The catalyst can be readily isolated by using an external magnet and no obvious loss of activity was observed when the catalyst was reused in five consecutive runs.

Keywords

γ-Fe2O3 nanoparticles, 1,1-diacetate

Chemoselective

Solvent free