Synthesis and DFT Calculation of a New Series of Enaminones based on 3-amino Coumarin

Document Type : Original Research Articles

Authors
Pegah Nouraie 1
Shahram Moradi Dehaghi 1
Alireza Foroumadi 2
1 Tehran North Branch, Islamic Azad University
2 Tehran University of Medical Sciences
10.22059/jsciences.2020.284918.1007425
Abstract
In this paper, the synthesis of various enaminones from the reaction of 3-aminocoumarin and ethyl-2,4-dioxo-4-arylbutanoate in the presence of p-toluene sulfonic acid is reported. The reaction was examined under different solvents and catalytic systems, which clearly proved the importance of acidic catalyst in this organic transformation. This work was also accompanied by density functional theory (DFT) studies to justify the formation of final products.
Keywords
3-aminocoumarin
Enaminones
DFT studies
Subjects
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Journal of Sciences, Islamic Republic of Iran
Volume 31, Issue 3
Summer 2020
Pages 213-220