THE DEALKYLATION OF TERTIARY AMINES WITH THIOPHOSGENE AND 1-CHLOROETHYL CHLOROTHIONOFORMATE

Abstract
Thiophosgene and 1-chloroethyl chlorothionoformate react readily with tertiary amines, and give the dialkylamine hydrochloride after hydrolysis of the initial product with water. Benzyl and allyl groups are cleaved in preference to methyl and other alkyl groups. The rection with the isoquinoline alkaloid narcotine occurs particularly easily.