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Green Synthesis, Characterization, and Biological Evaluation of Hydroxyl-Capped Tellurium Nanoparticles

Document Type : Original Paper

Authors

1 Biotechnology Research Center and Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

2 Department of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology and Poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

3 Department of Drug and Food Control, Faculty of Pharmacy and Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences Tehran, Islamic Republic of Iran

4 Department of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology and Poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran

Abstract

In this study, we used a simple green method for preparing tellurium nanoparticles and mainly evaluated their toxicological effects. The nanoparticles were synthesized using lactose and characterized with different instrumentation methods. The in vitro and in vivo cytotoxicity of tellurium nanoparticles and its effect on lipid profile were also evaluated. Hydroxyl-capped tellurium nanoparticles were successfully fabricated by lactose. The results showed spherical tellurium nanoparticles with a mean size of 89 nm. The toxicological study showed that the tellurium nanoparticles did not exhibit any toxicity on the primary cells. The LD50 values for the nanoparticles were 327 and 295 mg/kg for oral and intraperitoneal administrations, respectively. Also, the results showed a significant reduction in liver enzymes at the 16, 24, and 40 mg/kg doses. Hematological parameters indicated no significant suppressive changes between the animals that were administered tellurium nanoparticles and the control group. In addition, the effects of tellurium nanoparticles on hypercholesterolemic risk factors in mice fed with cholesterol demonstrated the depletion of triglyceride, cholesterol, and low-density lipoprotein. This study showed that the toxicity of tellurium nanoparticles was lower than tellurium ions. Furthermore, tellurium nanoparticles decreased the cholesterol and triglyceride levels in the animal model.

Keywords

References
  1. Faramarzi MA, Sadighi A. Insights into biogenic and chemical production of inorganic nanomaterials and nanostructures. Adv. Colloid. Interface. Sci. 2013;189–190:1–20.
  2. Wang H, Chai L, Xie Z, Zhang H. Recent advance of tellurium for biomedical applications. Chem. Res. Chinese. Univ. 2020;36(4): 551-559.
  3. Zare B, Faramarzi MA, Sepehrizadeh Z, Shakibaie M, Rezaie S, Shahverdi AR. Biosynthesis and recovery of rod-shaped tellurium nanoparticles and their bactericidal activities. Mater. Res. Bull. 2012;47(11):3719–25.
  4. Fadeel B, Garcia-Bennett AE. Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. Adv. Drug. Deliv. Rev. 2010;62(3):362–74.
  5. Ba LA, Döring M, Jamier V, Jacob C. Tellurium: an element with great biological potency and potential. Org. Biomol. Chem. 2010;8(19):4203–16.
  6. Amoozegar MA, Ashengroph M, Malekzadeh F, Reza Razavi M, Naddaf S, Kabiri M. Isolation and initial characterization of the tellurite reducing moderately halophilic bacterium, Salinicoccus sp. strain QW6. Microbiol. Res. 2008;163(4):456–65.
  7. Cunha RLOR, Gouvea IE, Juliano L. A glimpse on biological activities of tellurium compounds. An. Acad. Bras. Cienc. 2009;81(3):393–407.
  8. Turner RJ, Borghese R, Zannoni D. Microbial processing of Tellurium as a tool in biotechnology. Biotechnol. Adv. 2012;30(5):954–63..
  9. Sredni B. Immunomodulating tellurium compounds as anti-cancer agents. Semin. Cancer. Biol. 2012;22(1):60–9.
  10. Medina-Cruz D, Tien-Street W, Vernet-Crua A, Zhang B, Huang X, Murali A, et al. Tellurium, the forgotten element: A review of the properties, processes, and biomedical applications of the bulk and nanoscale metalloid. In: Racing for the Surface. Cham: Springer International Publishing; 2020. p. 723–83
  11. Zhang T, Doert T, Schwedtmann K, Weigand JJ, Ruck M. Facile synthesis of tellurium nano- and microstructures by trace HCl in ionic liquids. Dalton. Trans. 2020;49(6):1891–6.
  12. Morena AG, Bassegoda A, Hoyo J, Tzanov T. Hybrid tellurium-lignin nanoparticles with enhanced antibacterial properties. ACS. Appl. Mater. Interfaces. 2021;13(13):14885–93.
  13. Iesari F, Hatada K, Patel J, Balasubramanian C, Miyanaga T, Ikemoto H. Characterization of Te nanoparticles synthesized by plasma processing. Radiat. Phys. Chem. Oxf. Engl. 2020.
  14. Krug P, Wiktorska K, Kaczyńska K, Ofiara K, Szterk A, Kuśmierz B, et al. Sulforaphane-assisted preparation of tellurium flower-like nanoparticles. Nanotechnology. 2020;31(5):055603.
  15. Wafaa K. Khalef, Thoria R. Marzoog, Abdulqader D. Faisal. Synthesis and characterization of tellurium oxide nanoparticles using pulse laser ablation and study their antibacterial activity. J. Phys. Conf. Ser. 2021; 1795.
  16. Raveendran P, Fu J, Wallen SL. A simple and “green” method for the synthesis of Au, Ag, and Au–Ag alloy nanoparticles. Green. Chem. 2006;8(1):34–8.
  17. Huang H, Yang X. Synthesis of polysaccharide-stabilized gold and silver nanoparticles: a green method. Carbohydr. Res. 2004;339(15):2627–31.
  18. Shervani Z, Yamamoto Y. Carbohydrate-directed synthesis of silver and gold nanoparticles: effect of the structure of carbohydrates and reducing agents on the size and morphology of the composites. Carbohydr. Res. 2011;346(5):651–8.
  19. Vigneshwaran N, Nachane RP, Balasubramanya RH, Varadarajan PV. A novel one-pot “green” synthesis of stable silver nanoparticles using soluble starch. Carbohydr. Res. 2006;341(12):2012–8.
  20. Park Y, Hong YN, Weyers A, Kim YS, Linhardt RJ. Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles. IET. Nanobiotechnol. 2011;5(3):69–78.
  21. Wei TY, Chang HY, Huang CC. Synthesis of tellurium nanotubes via a green approach for detection and removal of mercury ions. RSC. Adv. 2013;3(33):13983.
  22. Lu Q, Gao F, Komarneni S. A green chemical approach to the synthesis of tellurium nanowires. Langmuir. 2005;21(13):6002–5.

 

  1. Medina Cruz D, Tien-Street W, Zhang B, Huang X, Vernet Crua A, Nieto-Argüello A, et al. Citric juice-mediated synthesis of tellurium nanoparticles with antimicrobial and anticancer properties. Green. Chem. 2019;21(8):1982–8.
  2. Kaur P, Yousuf S, Ansari MA, Ahmad AS, Islam F. Dose- and duration-dependent alterations by Tellurium on lipid levels: differential effects in cerebrum, cerebellum, and brain stem of mice. Biol. Trace. Elem. Res. 2003;94(3):259–71.
  3. Chugh A, Ray A, Gupta JB. Squalene epoxidase as hypocholesterolemic drug target revisited. Prog. Lipid. Res. 2003;42(1):37–50.
  4. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 1987;47(4):936–42.
  5. Hasimun P, Sukandar E.Y, Adnyana I.K, Tjahjono D.H. A Simple Method for Screening Antihyperlipidemic Agents. Int. J. Pharmacol. 2011;7: 74-78.
  6. Mirjani R, Faramarzi MA, Sharifzadeh M, Setayesh N, Khoshayand MR, Shahverdi AR. Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle-enriched probiotics on the lipid profiles of mice. IET. Nanobiotechnol. 2015;9(5):300–5.
  7. Gautam UK, Rao CNR. Controlled synthesis of crystalline tellurium nanorods, nanowires, nanobelts and related structures by a self-seeding solution process. J. Mater. Chem. 2004;14(16):2530.
  8. Qi ZM, Zhou HS, Matsuda N, Honma I, Shimada K, Takatsu A, et al. Characterization of gold nanoparticles synthesized using sucrose by seeding formation in the solid phase and seeding growth in aqueous solution. J. Phys. Chem. B. 2004;108(22):7006–11.
  9. Virkutyte J, Varma RS. Green synthesis of metal nanoparticles: Biodegradable polymers and enzymes in stabilization and surface functionalization. Chem. Sci. 2011;2(5):837–46.
  10. Vij P, Hardej D. Evaluation of tellurium toxicity in transformed and non-transformed human colon cells. Environ. Toxicol. Pharmacol. 2012;34(3):768–82.
  11. Roy S, Hardej D. Tellurium tetrachloride and diphenyl ditelluride cause cytotoxicity in rat hippocampal astrocytes. Food. Chem. Toxicol. 2011;49(10):2564–74.
  12. Meotti FC, Borges VC, Zeni G, Rocha JBT, Nogueira CW. Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice. Toxicol. Lett. 2003;143(1):9–16.
  13.  

 
  • Najimi S, Shakibaie M, Jafari E, Ameri A, Rahimi N, Forootanfar H, et al. Acute and subacute toxicities of biogenic tellurium nanorods in mice. Regul. Toxicol. Pharmacol. 2017; 90:222–30.
  1. Zare B, Nami M, Shahverdi A-R. Tracing Tellurium and its nanostructures in biology. Biol. Trace. Elem. Res. 2017;180(2):171–81.
  2. Lee KJ, Choi JH, Jeong HG. Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food. Chem. Toxicol. 2007;45(11):2118–25.
  3. Laden BP, Porter TD. Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls. J. Lipid. Res. 2001;42(2):235–40.
  4. Zare B, Sepehrizadeh Z, Faramarzi MA, Soltany-Rezaee-Rad M, Rezaie S, Shahverdi AR. Antifungal activity of biogenic tellurium nanoparticles against Candida albicans and its effects on squalene monooxygenase gene expression: Antifungal Activity of Biogenic Tellurium Nanoparticles. Biotechnol. Appl. Biochem. 2014;61(4):395–400.
  5. Kaur P, Yousuf S, Ansari MA, Siddiqui A, Ahmad AS, Islam F. Tellurium-induced dose-dependent impairment of antioxidant status: differential effects in cerebrum, cerebellum, and brainstem of mice. Biol. Trace. Elem. Res. 2003;94(3):247–58.
  6. Chetty KN, Calahan L, Harris KC, Dorsey W, Hill D, Chetty S, et al. garlic attenuates hypercholesterolemic risk factors in olive oil fed rats and high cholesterol fed rats. Pathophysiology. 2003;9(3):127–32.
  7. Sharma VK, Yngard RA, Lin Y. Silver nanoparticles: green synthesis and their antimicrobial activities. Adv. Colloid. Interface. Sci. 2009;145(1–2):83–96.
  8. Singh S, Bharti A, Meena VK. Structural, thermal, zeta potential and electrical properties of disaccharide reduced silver nanoparticles. J. Mater. Sci: Mater. Electron. 2014;25(9):3747–52.
  9. Wang H, Chai L, Xie Z, Zhang H. Recent advance of Tellurium for biomedical applications. Chem. Res. Chin. Univ. 2020;36(4):551–9.
  10. Wang M, Wang J, Sun H, Han S, Feng S, Shi L, et al. Time-dependent toxicity of cadmium telluride quantum dots on liver and kidneys in mice: histopathological changes with elevated free cadmium ions and hydroxyl radicals. Int. J. Nanomedicine. 2016; 11:2319–28.
Journal of Sciences, Islamic Republic of Iran
Volume 32, Issue 4
December 2021
Pages 321-330
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